Anatomical Distribution and Prevalence of Dysplasia in Sessile Serrated Lesions: A Cohort Study Over Seven Years
Natalie Dierick, Michael Wu, Christina Lee, Simon Palfreeman, Bethan Butler, Stuart Kostalas · 2026
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Description
Dierick and colleagues analysed in 2026 how often a precancerous colon lesion type carries dysplasia, a step toward cancer. Sessile serrated lesions are flat polyps that can progress to bowel cancer through a dysplasia stage. Pathology reports for 3,570 lesions were reviewed and terms standardised to current World Health Organization classes.
Initial reports flagged dysplasia in 102 lesions. After expert meeting review, nine were reclassified as other lesion types or as lacking dysplasia, leaving 93 confirmed cases, about 2.6 percent of lesions. Dysplasia rates did not differ significantly between the right and left sides of the colon, nor at any single site. The authors conclude dysplasia is spread evenly through the colon in this setting, so vigilance cannot focus on one region.
Catalog record
| CREATOR | Natalie Dierick, Michael Wu, Christina Lee, Simon Palfreeman, Bethan Butler, Stuart Kostalas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |