Dual targeting of PDPN and GD2 enhances CAR T cell efficacy against glioblastoma and promotes durable tumor control
Julian Hübner, Thomas Nerreter · 2026
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Description
Julian Hubner and Thomas Nerreter summarized work on engineered T cells that hunt two targets on a deadly brain tumor in a 2026 paper. Glioblastoma almost always kills despite surgery and chemoradiation. Cell therapy has cured some blood cancers but stalls in solid tumors, where targets vary and the setting suppresses immunity.
Screening fresh tumor samples and stained tissue pointed to two surface marks found across the tumors, richer still when tumors returned. A therapy aimed at both marks was built for local delivery into the tumor site. The paper recounts why the pair was chosen and how the dual aim answers the tumor's mixed makeup. The authors present the approach as a route to lasting control of a cancer that usually escapes single targets.
Catalog record
| CREATOR | Julian Hübner, Thomas Nerreter |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |