Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice
Michaela Dworsky-Fried, Umar Haris Iqbal, Stéphane Bronner, Jérémie Auger, Olivier Mathieu, Noémie Auclair-Ouellet, Jacky Liang, Nafissa Ismail · 2026
Read Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice by Michaela Dworsky-Fried, Umar Haris Iqbal, Stéphane Bronner, Jérémie Auger, Olivier Mathieu, Noémie Auclair-Ouellet, Jacky Liang, Nafissa Ismail (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571149.txt.
Description
Michaela Dworsky-Fried and co-authors published a mouse study in 2026 on how stress type and sex shape responses during puberty. Puberty is a sensitive window when stress can leave lasting marks on behavior, immunity, and the gut-brain link. The team compared two stress setups in young mice of both sexes: weeks of varied unpredictable stress, or a week of sleep disruption. One hundred mice took part.
Behavior tests showed effects that depended on both stressor and sex. Blood immune signals rose in distinct patterns across groups. Brain gene activity shifted in opposite directions in males and females in some regions. Gut microbe changes were strongest after sleep disruption and shorter stress. The authors stress that stressor type matters as much as sex.
Catalog record
| CREATOR | Michaela Dworsky-Fried, Umar Haris Iqbal, Stéphane Bronner, Jérémie Auger, Olivier Mathieu, Noémie Auclair-Ouellet, Jacky Liang, Nafissa Ismail |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |