Single-cell transcriptomics reveals that tenocyte-derived MIF contributes to tendon injury pathogenesis
Cheuk Hin Kot, Xiaojie Xu, Peifeng Hong, Xu Liang, Gerun Chen, Zebin Ma · 2026
Read Single-cell transcriptomics reveals that tenocyte-derived MIF contributes to tendon injury pathogenesis by Cheuk Hin Kot, Xiaojie Xu, Peifeng Hong, Xu Liang, Gerun Chen, Zebin Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571148.txt.
Description
Cheuk Hin Kot and co-authors use single-cell gene data to probe tendon injury in a 2026 study. Hurt tendons heal with swelling and poor tissue change, but the cell-level steps behind that harm have stayed unclear.
The team re-read data from across the healing span and found eight groups of tissue cells and eight groups of immune cells. Signals from one cell group, tied to a factor named MIF, grew strong in the early phase of injury. In mice, a drug that blocks that factor, packed in a gel set by light, cut swelling and bone-like change and left the tissue in better shape. The authors say the factor and the gel merit more tests as a path to care.
Catalog record
| CREATOR | Cheuk Hin Kot, Xiaojie Xu, Peifeng Hong, Xu Liang, Gerun Chen, Zebin Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |