Salidroside Attenuates High-Altitude Hypoxic Myocardial Injury Through Modulation of Oxidative Stress and AKT/GSK-3β Signaling Pathways
Danzeng Awang, Zong La, Kangzhuo Baima, Hongjun Xie, Li Wang, Xinyao Liu, Yueying Wang, Yan Shi, Yicheng Zhao, Lanzi Gongga · 2026
Read Salidroside Attenuates High-Altitude Hypoxic Myocardial Injury Through Modulation of Oxidative Stress and AKT/GSK-3β Signaling Pathways by Danzeng Awang, Zong La, Kangzhuo Baima, Hongjun Xie, Li Wang, Xinyao Liu, Yueying Wang, Yan Shi, Yicheng Zhao, Lanzi Gongga (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570824.txt.
Description
Danzeng Awang and colleagues tested whether salidroside, a Rhodiola compound, protects the heart from low-oxygen injury, publishing the study in 2026. High-altitude hypoxia strains the oxygen-hungry heart, driving oxidative stress, mitochondrial failure, and cell death, while current drugs carry notable side effects. The team combined network pharmacology and docking with experiments in cobalt-chloride hypoxia models in cells and rats.
Salidroside improved cell survival, cut reactive oxygen species, restored mitochondrial energy output, and curbed cell death, while in rats it eased ECG abnormalities, heart-muscle injury, hypertrophy, and lung and liver damage. Mechanistic tests showed it steered a protective GSK-3β switch largely without Akt. The work supports salidroside as a candidate shield against hypoxia-related heart injury.
Catalog record
| CREATOR | Danzeng Awang, Zong La, Kangzhuo Baima, Hongjun Xie, Li Wang, Xinyao Liu, Yueying Wang, Yan Shi, Yicheng Zhao, Lanzi Gongga |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |