Whole-mount diffracted X-ray blinking analysis of intracellular amyloid-β-associated nanoscale dynamics in Caenorhabditis elegans
Kotaro Ozaki, Yoichi Shinkai, Yuji C Sasaki, Masahiro Kuramochi · 2026
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Description
Kotaro Ozaki, Yoichi Shinkai, Yuji Sasaki, and Masahiro Kuramochi track tiny protein motions inside a whole worm in this 2026 study. The protein is amyloid-beta, the building block of Alzheimer's plaques. Watching how it moves at tiny scales inside tissue has been very hard.
Their method flashes X-rays through fixed whole worms and watches the sparkle pattern flicker over time. Gold particles tagged to the protein gave a readable signal without cutting the worm open. Protein in muscle cells showed more fast-relaxing parts than protein in nerve cells. Lab tests on the pure protein showed similar motion shifts as clumps formed. The method opens a way to study protein states in whole animals.
Catalog record
| CREATOR | Kotaro Ozaki, Yoichi Shinkai, Yuji C Sasaki, Masahiro Kuramochi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |