Comparative Efficacy and Safety of Tirzepatide Versus Semaglutide for Obesity: A Systematic Review
Samih Abdelmutalab Mohamed Abdalla, Lima Gharbawi, Namaa Elshaikh, Eltayeb Osman Elfaki Omer, Alaa Fathelrahman Mokhtar Osman, Asjed Salaheldin Hassan Ali, Tasneem Mohamed Yousif Mohamed, Ali Hadi M Alhajri · 2026
Read Comparative Efficacy and Safety of Tirzepatide Versus Semaglutide for Obesity: A Systematic Review by Samih Abdelmutalab Mohamed Abdalla, Lima Gharbawi, Namaa Elshaikh, Eltayeb Osman Elfaki Omer, Alaa Fathelrahman Mokhtar Osman, Asjed Salaheldin Hassan Ali, Tasneem Mohamed Yousif Mohamed, Ali Hadi M Alhajri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570719.txt.
Description
Samih Abdelmutalab Mohamed Abdalla and co-authors compare the two strongest injectable obesity drugs in a 2026 review. Tirzepatide acts on two gut hormone receptors, while semaglutide acts on one. Until recently the two were compared only across separate trials. A direct head-to-head trial and many real-world studies now allow a formal review.
Eleven studies covering about sixty-two thousand seven hundred patients were included. Tirzepatide produced greater weight loss in every study that tested the contrast. In the randomized trial, average loss at seventy-two weeks was about twenty percent against about fourteen percent. Real-world gaps were smaller, at a few percentage points. Stomach side effects dominated for both drugs. The authors rate the edge as real but smaller in routine care than in the trial.
Catalog record
| CREATOR | Samih Abdelmutalab Mohamed Abdalla, Lima Gharbawi, Namaa Elshaikh, Eltayeb Osman Elfaki Omer, Alaa Fathelrahman Mokhtar Osman, Asjed Salaheldin Hassan Ali, Tasneem Mohamed Yousif Mohamed, Ali Hadi M Alhajri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |