Synergistic Interaction Between PEAR1-FGB and the Dominant Role of ABCB1 in Thrombosis Risk: A SHAP and MDR-Based Study in Vietnamese Pedigrees
Hai Bui Hoang, Trang Thi Nguyen, Anh Ngoc Thi Le, Dan Hoang Le, Huy Quang Do, Sang Thanh Nguyen, Ha Thu Thi To, Thuy Thu Thi Nguyen, Hanh Minh Thi Nguyen · 2026
Read Synergistic Interaction Between PEAR1-FGB and the Dominant Role of ABCB1 in Thrombosis Risk: A SHAP and MDR-Based Study in Vietnamese Pedigrees by Hai Bui Hoang, Trang Thi Nguyen, Anh Ngoc Thi Le, Dan Hoang Le, Huy Quang Do, Sang Thanh Nguyen, Ha Thu Thi To, Thuy Thu Thi Nguyen, Hanh Minh Thi Nguyen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570623.txt.
Description
Hai Hoang and co-authors hunt for gene combinations that raise clotting risk in Vietnamese families, in this 2026 paper. Blood clots run in families, yet gene-to-gene effects are little studied in Southeast Asia. Single-gene checks miss risks that only appear when variants combine.
The study covered eighty-eight people from families with early vein clots, including nineteen patients. Sequencing found their variants, and two analysis tools split the work: one ranks each factor's weight, the other detects interactions. A gene pair showed a joint effect, while one gene, ABCB1, dominated alone. The authors aim to sharpen risk sorting for such families.
Catalog record
| CREATOR | Hai Bui Hoang, Trang Thi Nguyen, Anh Ngoc Thi Le, Dan Hoang Le, Huy Quang Do, Sang Thanh Nguyen, Ha Thu Thi To, Thuy Thu Thi Nguyen, Hanh Minh Thi Nguyen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |