Research Advances in Nanodrugs Targeting Lipid Metabolism Reprogramming for Colorectal Cancer Therapy
Jingwen Tang, Mengnan Liu, Ruizhi Zhang, Qiang Li, Shengtao Wang, Yuehua Wang · 2026
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Description
Jingwen Tang and five co-authors review nanodrugs that attack colon cancer through its fat metabolism, in this 2026 paper. Colorectal cancer ranks among the world's heaviest cancer burdens, and standard treatments falter against varied tumors, drug resistance, and side effects. These tumors also rewire how they make and burn fats, a weakness that tiny drug carriers might exploit.
The review gathers platforms that deliver blockers of fat-making enzymes and of two growth pathways, PI3K/AKT and Wnt. Designs range from carrier-free particles to cages coated in red blood cell membrane and particles that answer to cholesterol. The authors weigh what blocks clinic use: tumor variety, safety, mass production, and thin trial data. They close with trends that might carry these ideas into care.
Catalog record
| CREATOR | Jingwen Tang, Mengnan Liu, Ruizhi Zhang, Qiang Li, Shengtao Wang, Yuehua Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |