C–X–C Motif Chemokine Receptor 4 (CXCR4)‐Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited‐Stage Small Cell Lung Cancer
Keru Pu, Tengxiang Li, Shengnan Xu, Xue Sha, Qingtao Qiu, Jinming Yu, Yong Yin, Jie Liu · 2026
Read C–X–C Motif Chemokine Receptor 4 (CXCR4)‐Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited‐Stage Small Cell Lung Cancer by Keru Pu, Tengxiang Li, Shengnan Xu, Xue Sha, Qingtao Qiu, Jinming Yu, Yong Yin, Jie Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570430.txt.
Description
Bulky lung tumors resist standard radiation, so doctors are testing radiation laid down in a spaced grid instead of an even wash. Keru Pu and co-authors checked a guided version of that grid in this 2026 study. A scan tracer lights up tumor zones rich in a receptor called CXCR4. Proton beams then aim their peaks at the lit zones.
Thirty patients with bulky, limited-stage small cell lung cancer took part. Scan readings matched the tumor outlines drawn from standard images well. The lit sub-volumes were compared with zones that partial-tumor methods would target. Dose plans stayed within safe limits for nearby organs. Image-guided proton grids could sharpen treatment where even dosing fails.
Catalog record
| CREATOR | Keru Pu, Tengxiang Li, Shengnan Xu, Xue Sha, Qingtao Qiu, Jinming Yu, Yong Yin, Jie Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |