Supercritical Solution Impregnation: A Strategy to Prevent Prosthetic Infections
Andrea Salas, Sara Díaz, Eduardo Pérez, Helga K. Ruiz, Rama Hafian, Pablo Sanz, Lourdes Calvo, Albertina Cabañas · 2026
Read Supercritical Solution Impregnation: A Strategy to Prevent Prosthetic Infections by Andrea Salas, Sara Díaz, Eduardo Pérez, Helga K. Ruiz, Rama Hafian, Pablo Sanz, Lourdes Calvo, Albertina Cabañas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570330.txt.
Description
Andrea Salas and seven colleagues present a 2026 study on loading antibiotics into replacement joints before they ever reach a patient. Infection around a prosthesis is among the most dreaded complications in orthopedic surgery. The team used supercritical carbon dioxide, a fluid that behaves like both gas and liquid, as a clean carrier that soaks the drug into the joint's plastic liner.
Working with real knee liner pieces, they dissolved the antibiotic clindamycin in the fluid under heat and pressure. Loadings were modest, capped by the dense plastic, and rose with fluid density and faster pressure release. The treated pieces carried no solvent residue and killed staph bacteria in dish tests, forming clear halos. The authors call it a green route to self-defending implants.
Catalog record
| CREATOR | Andrea Salas, Sara Díaz, Eduardo Pérez, Helga K. Ruiz, Rama Hafian, Pablo Sanz, Lourdes Calvo, Albertina Cabañas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |