Cepheid 9-gene host mRNA expression across the spectrum of Mycobacterium tuberculosis infection and disease: insights across the lifespan
Marva Seifert, Michael Gracia, Donald G. Catanzaro, Faiqa Rashid, Rehan R. Syed, Faisal Masood, Naomi Hillery, Alamdar Hussain, Ashley Swing, Rebecca E. Colman, Uzma Majeed, Antonino Catanzaro, Sabira Tahseen, Timothy C. Rodwell · 2026
Read Cepheid 9-gene host mRNA expression across the spectrum of Mycobacterium tuberculosis infection and disease: insights across the lifespan by Marva Seifert, Michael Gracia, Donald G. Catanzaro, Faiqa Rashid, Rehan R. Syed, Faisal Masood, Naomi Hillery, Alamdar Hussain, Ashley Swing, Rebecca E. Colman, Uzma Majeed, Antonino Catanzaro, Sabira Tahseen, Timothy C. Rodwell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570273.txt.
Description
Marva Seifert and thirteen co-authors tested whether a blood gene signature can sort people by tuberculosis status, and whether age changes how well it works. The assay reads host genes whose activity differs among people with active disease, people infected but not sick, and people with no infection. They ran it on samples from about 450 people grouped as adolescents and young adults, middle adults, and older adults.
Three genes best flagged any infection, and four others best separated active disease from the rest. Classifiers built from those genes performed strongly in the youngest group, with accuracy scores near 0.89, but faded with age, dropping to about 0.56 for disease detection in older adults. The authors conclude that immune aging blurs these signatures. Host-response tests for tuberculosis, they argue, may serve young people best and must be judged separately in each age band.
Catalog record
| CREATOR | Marva Seifert, Michael Gracia, Donald G. Catanzaro, Faiqa Rashid, Rehan R. Syed, Faisal Masood, Naomi Hillery, Alamdar Hussain, Ashley Swing, Rebecca E. Colman, Uzma Majeed, Antonino Catanzaro, Sabira Tahseen, Timothy C. Rodwell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |