Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu · 2026
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Description
Sheng Ma and co-authors review the cell's stress proteins as cancer targets in a 2026 paper. Heat shock proteins are chaperones: they fold, carry, and guard other proteins. Tumors lean on them hard, because cancer's fast, stressed metabolism floods the cell with fragile proteins. The review integrates structural, lab, and clinical evidence across the main chaperone families.
The authors show how the chaperones' cycles and cages steady the enzymes and transporters that run tumor metabolism, from sugar burning to the cell's power plants. That support buys tumors survival and drug resistance. But dependence is also a weakness. The review weighs drugs that block the chaperones, break their partnerships, or aim the immune system at them, plus biomarker-guided combinations.
Catalog record
| CREATOR | Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 115 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |