Integrative analysis of single‐cell multi‐omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease
Jiayue Meng, Miaomiao Zhang, Yujie Chen, Mengyao Han, Nianhao Cheng, Ruifang Cao, Qinwen He, Yaya Zhao, Liyun Yuan, Guoqing Zhang · 2026
Read Integrative analysis of single‐cell multi‐omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease by Jiayue Meng, Miaomiao Zhang, Yujie Chen, Mengyao Han, Nianhao Cheng, Ruifang Cao, Qinwen He, Yaya Zhao, Liyun Yuan, Guoqing Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570217.txt.
Description
Jiayue Meng and co-authors mapped in 2026 the cell types of the brain's smell cortex and found one group of neurons that Alzheimer's disease hits early. Combining gene activity and gene regulation data cell by cell, they split the region's main neurons into four subtypes with distinct locations. One subtype, marked by a protein called Reln, sat where amyloid plaques gather.
In Alzheimer's mouse models that subtype shrank, confirmed by tissue staining. The same cells shared a molecular signature with vulnerable neurons in a neighboring memory region. In human disease the signature grew stronger across early stages. A related gene module tied to protein housekeeping also emerged. The authors say shared vulnerability programs may explain the disease's selective pattern.
Catalog record
| CREATOR | Jiayue Meng, Miaomiao Zhang, Yujie Chen, Mengyao Han, Nianhao Cheng, Ruifang Cao, Qinwen He, Yaya Zhao, Liyun Yuan, Guoqing Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |