Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C Marcogliese, Geoffrey K Tranmer · 2026
Read Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS) by Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C Marcogliese, Geoffrey K Tranmer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570208.txt.
Description
Nitesh Sanghai and co-authors review recent work on getting drugs past the blood-brain barrier in amyotrophic lateral sclerosis, often called ALS. The disease slowly kills the nerve cells that control movement, and few treatments exist. The review covers both the barrier around the brain and the matching barrier around the spinal cord.
The authors pull together studies on how these barriers break down as the disease goes on. They describe loose cell joints, leaky vessel walls, and changes in the pumps that move substances in and out. The evidence suggests that barrier damage starts early and is part of the disease itself, not just a late effect. The review then looks at new ways to bypass, use, or repair the barrier so that more of a drug reaches the nervous system. Knowing how the barrier changes at each stage could help doctors time and target future treatments.
Catalog record
| CREATOR | Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C Marcogliese, Geoffrey K Tranmer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |