Tear MicroRNA-Based Molecular Signature for Keratoconus Stratification: A Cross-Cohort Integration Study
Shao-Hsuan Chang, Kuo-Hsuan Hung, Hsieh-Fu Tsai, Chung-Pei Ma, Hao-Chang Chiang, Lung-Kun Yeh · 2026
Read Tear MicroRNA-Based Molecular Signature for Keratoconus Stratification: A Cross-Cohort Integration Study by Shao-Hsuan Chang, Kuo-Hsuan Hung, Hsieh-Fu Tsai, Chung-Pei Ma, Hao-Chang Chiang, Lung-Kun Yeh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570024.txt.
Description
Shao-Hsuan Chang and five co-authors hunt for a tear-based molecular signature of keratoconus, in a study from twenty twenty-six. The disease slowly thins and bulges the cornea. Whether tiny RNA strands in tears mirror the cornea's molecular changes was unknown.
The team mined three public corneal gene datasets and found immune-linked shifts in diseased tissue. In a small tear cohort they profiled the tiny RNAs and picked a five-member signature. The signature separated patients from controls in an independent dataset, and one member was consistently lowered across all sources. A combined index mixing that RNA with corneal steepness tracked disease shape closely. The authors say tear RNAs may add molecular detail to eye exams, pending more work.
Catalog record
| CREATOR | Shao-Hsuan Chang, Kuo-Hsuan Hung, Hsieh-Fu Tsai, Chung-Pei Ma, Hao-Chang Chiang, Lung-Kun Yeh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |