Efficacy and safety of daratumumab-based quadruplet therapy vs non-daratumumab-based triplet therapy in newly diagnosed multiple myeloma patients: A GRADE assessed systematic review and meta-analysis of randomized controlled trials
Muhammad Osama, Muhammad Haris Khan, Ammara Tahir, Amna Hussain, Ahmad Iftikhar, Aizaz Ali, Safeena Khan, Malak Bilal Hassan, Intikhab Alam, Zeeshan Khan, Abdullah Afridi, Mohammad Ebad Ur Rehman, Amna Gul, Pawan Kumar Thada · 2026
Read Efficacy and safety of daratumumab-based quadruplet therapy vs non-daratumumab-based triplet therapy in newly diagnosed multiple myeloma patients: A GRADE assessed systematic review and meta-analysis of randomized controlled trials by Muhammad Osama, Muhammad Haris Khan, Ammara Tahir, Amna Hussain, Ahmad Iftikhar, Aizaz Ali, Safeena Khan, Malak Bilal Hassan, Intikhab Alam, Zeeshan Khan, Abdullah Afridi, Mohammad Ebad Ur Rehman, Amna Gul, Pawan Kumar Thada (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13570013.txt.
Description
Multiple myeloma is the second most common blood cancer, and adding an antibody drug to standard triplets has raised hopes for new patients. Muhammad Osama and co-authors pool the trial evidence in a 2026 review and meta-analysis. They compare four-drug plans built on daratumumab against three-drug plans without it.
The search covered four sources up to April 2026 and gathered seven randomized trials. The main measures were time before the disease progressed and whether any trace of disease remained. The team also split results by the genetic risk grade of the cancer. Evidence quality was graded with a standard framework, which helps readers judge how much trust the pooled numbers deserve.
Catalog record
| CREATOR | Muhammad Osama, Muhammad Haris Khan, Ammara Tahir, Amna Hussain, Ahmad Iftikhar, Aizaz Ali, Safeena Khan, Malak Bilal Hassan, Intikhab Alam, Zeeshan Khan, Abdullah Afridi, Mohammad Ebad Ur Rehman, Amna Gul, Pawan Kumar Thada |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |