Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers
Lorenzo Pagano, Claudia Saraceno, Andrea Geviti, Silvia Fostinelli, Alessandro Facconi, Valentina Laganà, Giulia Giacomucci, Maria Sofia Cotelli, Assunta Ingannato, Silvia Bagnoli, Antonio Longobardi, Alice Russotto, Sonia Bellini, Davide Lagrotteria, Ersilia Paparazzo, Giuliano Binetti, Alberto Mon · 2026
Read Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers by Lorenzo Pagano, Claudia Saraceno, Andrea Geviti, Silvia Fostinelli, Alessandro Facconi, Valentina Laganà, Giulia Giacomucci, Maria Sofia Cotelli, Assunta Ingannato, Silvia Bagnoli, Antonio Longobardi, Alice Russotto, Sonia Bellini, Davide Lagrotteria, Ersilia Paparazzo, Giuliano Binetti, Alberto Mon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13569440.txt.
Description
Lorenzo Pagano and a large team of co-authors study a gene variant that may delay frontotemporal dementia in work dated two thousand twenty-six. Changes in the granulin gene are a top cause of that dementia, yet age of onset varies a lot, even within one family. Other genes likely tune the course.
A variant in a related gene, TMEM106B, had been tied to lower risk in past work. The team screened one hundred eighty-seven carriers of granulin changes in Italy, the largest such group yet for this variant. They tracked how the variant relates to age at onset, survival, and levels of the granulin protein. Carriers of two copies of the shielding form are a key group in the study.
Catalog record
| CREATOR | Lorenzo Pagano, Claudia Saraceno, Andrea Geviti, Silvia Fostinelli, Alessandro Facconi, Valentina Laganà, Giulia Giacomucci, Maria Sofia Cotelli, Assunta Ingannato, Silvia Bagnoli, Antonio Longobardi, Alice Russotto, Sonia Bellini, Davide Lagrotteria, Ersilia Paparazzo, Giuliano Binetti, Alberto Mon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |