Rethinking schizophrenia: insights from genomics and implications for research
Michael J Owen, Michael C O’Donovan · 2026
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Description
Michael Owen and Michael O'Donovan rethink schizophrenia through its genetics in a 2026 review. Gene studies now speak loudly about the illness, and the pair read them against the wider evidence. Their picture spans the whole lifespan.
Genetic risk acts from fetal life into adulthood, across many neuron types and brain regions. The illness looks mainly neuronal, with faulty synapses at the center, in both development and adult function. Non-inherited genes and environment drive much of the developmental damage, often visible as cognition below family expectation. Weak thinking and brain structure mark vulnerability rather than causing symptoms. The disorder sits on a continuum with childhood conditions, they argue.
Catalog record
| CREATOR | Michael J Owen, Michael C O’Donovan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |