Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity
Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim · 2026
Read Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity by Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13569226.txt.
Description
Soyeon Park and co-authors map how a scarred liver rewires the body's handling of cortisol, in a 2026 study. Cirrhosis often pairs with adrenal trouble, yet whether the liver itself steers the shift stayed unclear. The team profiled dozens of steroids in blood and saliva from 33 cirrhosis patients, healthy controls, and patients with true adrenal failure, before and after a hormone spur test.
Cirrhosis showed its own pattern, distinct from adrenal failure. Two breakdown routes ran low: the enzyme that reactivates cortisol and the A-ring path that clears it. A third route, a side reduction, ran hot. Key ratios, like peak cortisol against its spent form, fell in step with how sick the liver was. The authors say full steroid profiling can expose the rewiring and grade its depth, a tool for care and study alike.
Catalog record
| CREATOR | Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |