The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio · 2026
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Description
Javier Caviedes-Bucheli and colleagues review a little-studied brake on tooth pain: neuropeptide Y, a signalling molecule inside the dental pulp. The pulp is a densely wired, rigid tissue where inflammation can quickly raise pressure, choke blood flow, and cause pain. While two excitatory messengers, substance P and CGRP, are well known drivers of that spiral, neuropeptide Y's counterbalancing role has been underexplored. Their 2026 review synthesised 92 studies.
Across models, neuropeptide Y emerged as a master regulator that damps excitation, constricts vessels, and quiets pain-sensing nerves, partly by suppressing CGRP release. In decayed teeth its levels shift with disease stage, hinting at an early protective program that fails as damage advances. The authors frame pulp outcomes as a balance between excitatory and inhibitory signals, with neuropeptide Y as a potential therapeutic lever.
Catalog record
| CREATOR | Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |