Regulation of Template Ionization and Template–Monomer Interactions for Enhanced Molecular Imprinting and Selective Detection of Promethazine

Description

Yang Xing, Xuan Hao Lin, and Sam Fong Yau Li build a sensor that detects promethazine, a common sedating drug, with high selectivity. A quartz crystal is coated with plastic molded around the drug itself, a method called molecular imprinting. The team tuned the molding in two ways. They screened chemicals for the strongest grip on the template. They protonated the drug, so partners arranged around it more tightly before the plastic set.

The sensor answered in a straight line from 50 to 2,000 parts per billion, with a detection limit of twenty-seven point four. It ignored close chemical cousins, kept working in messy samples, and held ninety-seven point nine percent of its response after ten regeneration cycles. Spiked tap water and soda samples gave ninety-four point seven to one hundred twelve point six percent recovery. The authors offer the tuning rules for other basic drugs.

Catalog record

Source: https://europepmc.org/articles/PMC13568314