Acute and prolonged effects of anti-malarial drugs on mitochondrial respiration in atrial cardiomyocytes for cardiac safety evaluation
Rahme Nese Safakli, Bonn Lee, Karan R. Chadda, Savithri Sathivelu, Ioannis Smyrnias, Christopher L.H. Huang, Joel Tarning, Cesare Terracciano, Gary Tse, Charlotte E. Edling, Kamalan Jeevaratnam, José Luiz Vieira, José Luiz Vieira, José Luiz Vieira · 2026
Read Acute and prolonged effects of anti-malarial drugs on mitochondrial respiration in atrial cardiomyocytes for cardiac safety evaluation by Rahme Nese Safakli, Bonn Lee, Karan R. Chadda, Savithri Sathivelu, Ioannis Smyrnias, Christopher L.H. Huang, Joel Tarning, Cesare Terracciano, Gary Tse, Charlotte E. Edling, Kamalan Jeevaratnam, José Luiz Vieira, José Luiz Vieira, José Luiz Vieira (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13567763.txt.
Description
Rahme Safakli and co-authors check whether malaria drugs strain the heart's engines at the cellular level. Mass drug campaigns reach millions, and heart-safety worries shadow several antimalarials. Using human stem-cell-derived atrial heart cells and a flux analyzer, the team dosed single drugs and combinations, briefly and for long stretches, and measured how the cells breathe.
Mefloquine and its combinations cut respiration outright. Prolonged halofantrine shrank maximal breathing and spare capacity. Amodiaquine, artemether, chloroquine, and piperaquine left cell breathing intact at both exposures. Ivermectin hurt only with prolonged dosing, lowering coupling efficiency. The authors present the screen as early cardiac safety intelligence for elimination programs choosing drug combinations at population scale.
Catalog record
| CREATOR | Rahme Nese Safakli, Bonn Lee, Karan R. Chadda, Savithri Sathivelu, Ioannis Smyrnias, Christopher L.H. Huang, Joel Tarning, Cesare Terracciano, Gary Tse, Charlotte E. Edling, Kamalan Jeevaratnam, José Luiz Vieira, José Luiz Vieira, José Luiz Vieira |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |