Dual-Targeted Inhibition of PAR2 Endosomal Signaling in Synoviocytes and Nociceptors Attenuates Osteoarthritis Pain
Marcella de A. Ferreira, Paz Duran, Raquel Tonello, Veronica Emad Farag, Mae Stabile D’Ambra, Evan Yuhan Chen, Sher B. Poudel, Kam W. Leong, Dane D. Jensen · 2026
Read Dual-Targeted Inhibition of PAR2 Endosomal Signaling in Synoviocytes and Nociceptors Attenuates Osteoarthritis Pain by Marcella de A. Ferreira, Paz Duran, Raquel Tonello, Veronica Emad Farag, Mae Stabile D’Ambra, Evan Yuhan Chen, Sher B. Poudel, Kam W. Leong, Dane D. Jensen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13567674.txt.
Description
Marcella de A. Ferreira and co-authors report a 2026 study on joint pain in osteoarthritis, the wear-and-tear joint disease. A receptor called PAR2 sits on joint lining cells and on pain nerve endings, and it drives both swelling and pain. Drugs that block it wash out of the joint too fast to help for long.
The team packed a PAR2 blocker into tiny particles and tested the mix in mice with joint damage. The packed drug calmed joint cells and eased pain for longer than the free drug. Both nerve cells and joint cells took up the particles. Mice bred to lack PAR2 on pain nerves had less pain and moved better. Aimed delivery to both cell types looks like a sound plan for lasting relief.
Catalog record
| CREATOR | Marcella de A. Ferreira, Paz Duran, Raquel Tonello, Veronica Emad Farag, Mae Stabile D’Ambra, Evan Yuhan Chen, Sher B. Poudel, Kam W. Leong, Dane D. Jensen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |