Gold Nanoparticle-Mediated DNA Damage Under FLASH Electron-Beam Irradiation: A Monte Carlo Study
Chloe Doen Kim, James C. L. Chow · 2026
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Description
FLASH radiotherapy delivers radiation at ultrahigh dose rates and may spare healthy tissue while controlling tumors. Chloe Doen Kim and James Chow simulated how gold nanoparticles change DNA damage under FLASH electron-beam irradiation. Gold nanoparticles can amplify radiation effects by producing reactive oxygen species. Whether they still help under FLASH conditions was unclear. The twenty twenty-six study used Geant4-DNA Monte Carlo simulations to find out.
The simulations measured single- and double-strand DNA breaks from direct hits and from chemical radicals. Water nanoparticles served as controls. As dose rate rose, relative strand breaks fell for both damage routes. In the ten keV model condition, the ten-nanometer gold particle gave the strongest sensitization. The results map where nanoparticle enhancement survives FLASH delivery.
Catalog record
| CREATOR | Chloe Doen Kim, James C. L. Chow |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |