Structure-Based Screening Identifies Polyphenol Glucuronides as Cyclophilin D Ligands
Annan Wu, Jie Zhang, Jing Zhao · 2026
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Description
Annan Wu, Jie Zhang, and Jing Zhao screen plant compounds for a grip on a mitochondrial gatekeeper, in a 2026 paper. When cells are stressed, a pore in their power plants can jam open and wreck them. The gatekeeper protein helps decide that opening, so blocking it is a drug aim. The team first graded six known shapes of the protein for screening worth, using known blockers and thousands of decoys.
The best shape then ranked about 500 food plant compounds in a virtual screen. Members of one compound family, the glucuronides, floated to the top. Two of them were tested in the lab with magnet-based and surface-based tools, and both bound the protein directly at modest strength. Their touch points on the protein matched the screen's guess. The authors say the pipeline, test the shelf before you screen, saves wasted hunts.
Catalog record
| CREATOR | Annan Wu, Jie Zhang, Jing Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |