Formononetin Alleviates Cigarette Smoke Extract-Induced Lung Injury in Mice with Gut Microbiota and Taurine/SLC6A6/NF-κB Modulation
Zheng Ma, Sen Hu, Zhongting Lv, Shuang Liu, Jia Yu, Jie Zhang, Hui Tian, Li Ren · 2026
Read Formononetin Alleviates Cigarette Smoke Extract-Induced Lung Injury in Mice with Gut Microbiota and Taurine/SLC6A6/NF-κB Modulation by Zheng Ma, Sen Hu, Zhongting Lv, Shuang Liu, Jia Yu, Jie Zhang, Hui Tian, Li Ren (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13567225.txt.
Description
Zheng Ma and colleagues report a 2026 mouse study of a plant compound that may ease smoke damage to the lungs. Cigarette smoke is a top preventable cause of lung disease, driving oxidation and swelling in lung tissue. The compound, formononetin, comes from plants and is known to calm swelling and shape gut microbes.
Mice exposed to cigarette smoke extract fared better when fed the compound. Their lungs showed less tissue damage and lower swelling signals, and their weight gain improved. The gut lining also healed, with key sealing proteins restored. Deeper checks linked the benefit to shifts in gut microbes and to taurine, a nutrient the lungs had lost. A taurine transport protein recovered, and a major swelling switch was dialed down. The study ties lung protection to the gut in a fresh way.
Catalog record
| CREATOR | Zheng Ma, Sen Hu, Zhongting Lv, Shuang Liu, Jia Yu, Jie Zhang, Hui Tian, Li Ren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |