Design, Synthesis and Anticancer Evaluation of Novel SO2F-Containing Medicinally Privileged Structures via Ketone-Directed C–H Functionalization
Seungwan Kim, Lingayya Rajaka, Saegun Kim, In Jae Bang, Hyun Woo Lee, Minseo Choi, Jihyo Lee, Myunghwa Jung, Hyosik Woo, Sangil Han, Ki Yong Lee, Hyun Jin Kim, Ha Ryong Kim, Sang Hoon Han · 2026
Read Design, Synthesis and Anticancer Evaluation of Novel SO2F-Containing Medicinally Privileged Structures via Ketone-Directed C–H Functionalization by Seungwan Kim, Lingayya Rajaka, Saegun Kim, In Jae Bang, Hyun Woo Lee, Minseo Choi, Jihyo Lee, Myunghwa Jung, Hyosik Woo, Sangil Han, Ki Yong Lee, Hyun Jin Kim, Ha Ryong Kim, Sang Hoon Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13567039.txt.
Description
Seungwan Kim and a large team of co-authors report new routes to build drug like ring structures that carry a sulfur fluoride group, in a study from 2026. The group is prized in drug design because it can react in a clean, click like way inside the body. Placing it on valued ring systems with care is a useful synthetic step.
Their methods use rhodium or ruthenium guides and a ketone group on the ring to direct the reaction. Five families of rings were treated, from plant pigments to dye like systems. The products formed with high site selectivity and tolerated many other groups. Test reactions then linked the products to biological molecules and to DNA, and the set was screened against lung cancer cells in the lab.
Catalog record
| CREATOR | Seungwan Kim, Lingayya Rajaka, Saegun Kim, In Jae Bang, Hyun Woo Lee, Minseo Choi, Jihyo Lee, Myunghwa Jung, Hyosik Woo, Sangil Han, Ki Yong Lee, Hyun Jin Kim, Ha Ryong Kim, Sang Hoon Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |