Mitochondrial Distress Signals at the Heart–Liver Interface: Molecular Links Between MASLD and Heart Failure
Xing Yang, Kun Cheng, Chen Chen, Yuxin Zhang, Dao Wen Wang · 2026
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Description
Xing Yang and four co-authors review in a 2026 paper how stressed cell power plants link liver fat disease and heart failure. The two conditions often arrive together, and both show strain in the mitochondria, the parts of the cell that make energy, though the strain differs by stage and form.
In the fatty liver, energy burning first rises, then falters with weak quality control as disease deepens. In the failing heart, reserve energy shrinks and fuel choice shifts. The authors sort true organ-to-organ signals from shared strain: liver-made fuels and a growth factor, stray DNA that stirs inflammation, and tiny parcels that ferry cargo between organs. They warn that like signals alone do not prove direct talk.
Catalog record
| CREATOR | Xing Yang, Kun Cheng, Chen Chen, Yuxin Zhang, Dao Wen Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |