HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model
Kei Nakamura, Yuta Fujii, Yuji Arai, Shuji Nakagawa, Atsuo Inoue, Ryota Cha, Keisuke Sugie, Kentaro Hayashi, Tomoki Saito, Tsunao Kishida, Osam Mazda, Kenji Takahashi · 2026
Read HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model by Kei Nakamura, Yuta Fujii, Yuji Arai, Shuji Nakagawa, Atsuo Inoue, Ryota Cha, Keisuke Sugie, Kentaro Hayashi, Tomoki Saito, Tsunao Kishida, Osam Mazda, Kenji Takahashi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566677.txt.
Description
Kei Nakamura and eleven co-authors tested a drug for worn joints in rats in a 2026 study. Cartilage survives in low oxygen, and a protein that senses oxygen helps keep it healthy. In osteoarthritis that protein fades and cartilage breaks down. A drug that protects the protein is already used for anemia tied to kidney disease.
The drug, roxadustat, did not harm rat cartilage cells in dishes. It raised levels of the oxygen-sensing protein and of two building blocks of healthy cartilage. In 3D cell balls, it boosted the gel-like matrix that cushions joints. Injected into the knees of rats with induced joint damage, it slowed cartilage wear and improved standard damage scores. The authors say the drug class deserves study as a joint treatment, not just an anemia treatment.
Catalog record
| CREATOR | Kei Nakamura, Yuta Fujii, Yuji Arai, Shuji Nakagawa, Atsuo Inoue, Ryota Cha, Keisuke Sugie, Kentaro Hayashi, Tomoki Saito, Tsunao Kishida, Osam Mazda, Kenji Takahashi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |