Targeting NR4A1 (Nur77) in Macrophage Polarization: Molecular Mechanisms and Translational Prospects for Cardiac Repair After Myocardial Infarction
Jiaqian Lin, Jianmin Wang, Lei Sun, Rui Zhang · 2026
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Description
Lin, Wang, Sun, and Zhang review in twenty twenty-six a cell switch that may help hearts heal after a heart attack. A heart attack triggers sterile swelling that can scar the heart and lead to failure. Immune cells called macrophages can either fan that swelling or switch to a repair mode that calms it and rebuilds tissue.
The switch they focus on is a receptor that reprograms these cells toward repair. The review traces the pathways it controls, including a major swelling pathway and the cell's energy pathway. Repair-mode cells help grow new vessels, steady scar tissue, and rescue surviving heart cells. The authors also review nano-scale delivery to these cells and new small drugs that could turn the switch on.
Catalog record
| CREATOR | Jiaqian Lin, Jianmin Wang, Lei Sun, Rui Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |