Endogenous Expression of an RNA-Hydrolyzing Minibody Enhances the Therapeutic Effects Against Influenza a Virus Compared to Therapeutically Intranasal Administration
Quynh Xuan Thi Luong, Yongjun Lee, Chengmin Lin, Muhammad Salman Akram, Phuong Thi Ho, Phuong Thi Hoang, Ramadhani Qurrota Ayun, Thuy Thi Bich Vo, Taek-Kyun Lee, Sukchan Lee · 2026
Read Endogenous Expression of an RNA-Hydrolyzing Minibody Enhances the Therapeutic Effects Against Influenza a Virus Compared to Therapeutically Intranasal Administration by Quynh Xuan Thi Luong, Yongjun Lee, Chengmin Lin, Muhammad Salman Akram, Phuong Thi Ho, Phuong Thi Hoang, Ramadhani Qurrota Ayun, Thuy Thi Bich Vo, Taek-Kyun Lee, Sukchan Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566613.txt.
Description
Quynh Luong and co-authors test, in a 2026 study, a small antibody form that cuts viral RNA, as a shield against flu. Flu spreads fast and shifts its form, so drugs can lose their grip. The protein, 3D8 scFv, breaks both DNA and RNA of viruses and has shown wide antiviral force. The team first traced where the drug goes in mice by route and dose. Nose doses piled up in the lung; vein doses spread through the whole body, lung in the mix.
They then set two paths against a mouse flu strain. In one, the drug was given after infection. In the other, mouse cells made the drug on their own before infection. That built-in path saved all the mice, at 100 percent life. The dosed path saved a third. The gap makes a strong case for built-in guards.
Catalog record
| CREATOR | Quynh Xuan Thi Luong, Yongjun Lee, Chengmin Lin, Muhammad Salman Akram, Phuong Thi Ho, Phuong Thi Hoang, Ramadhani Qurrota Ayun, Thuy Thi Bich Vo, Taek-Kyun Lee, Sukchan Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |