Caenorhabditis elegans as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer’s Disease: Plant Bioactive Compounds and Therapeutic Translation
Aina Bellver-Sanchis, Nikola R. Ralchev, Patrizia R. Romanska, Nikoleta K. Dyakova, Kristina I. Ivanova, Christian Griñán-Ferré, Andrey S. Marchev · 2026
Read Caenorhabditis elegans as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer’s Disease: Plant Bioactive Compounds and Therapeutic Translation by Aina Bellver-Sanchis, Nikola R. Ralchev, Patrizia R. Romanska, Nikoleta K. Dyakova, Kristina I. Ivanova, Christian Griñán-Ferré, Andrey S. Marchev (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566524.txt.
Description
Aina Bellver-Sanchis and six co-authors review how a tiny worm can model Alzheimer's disease research, in a 2026 paper. The worm, Caenorhabditis elegans, lives briefly, has a clear body, and has a fully mapped nervous system. The review centers on a defense pathway that guards cells against oxidative stress. In worms the pathway runs through a protein called SKN-1, the counterpart of a human regulator named Nrf2.
The authors explain how that pathway changes in Alzheimer's disease and how plant compounds switch it on. They describe worm strains built to mimic parts of the disease, from protein clumps to tangles. They then discuss how findings in worms carry over to mammals and to human trials. The review also touches on tailoring treatments to each patient, a growing aim in the field.
Catalog record
| CREATOR | Aina Bellver-Sanchis, Nikola R. Ralchev, Patrizia R. Romanska, Nikoleta K. Dyakova, Kristina I. Ivanova, Christian Griñán-Ferré, Andrey S. Marchev |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 152 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |