The Clinical Factors Associated with Clazosentan Discontinuation and Exploratory Associations with Discharge and Six-Month Outcomes in Aneurysmal Subarachnoid Hemorrhage: A Multicenter DCI Japan Registry Study
Yusuke Inoue, Masahito Katsuki, Toshikazu Hidaka, Yukishige Hashimoto, Yusuke Yamamoto, Daizo Ishii, Katsumi Takizawa, Yoji Tanaka, Masaki Chin, Motohiro Morioka, Hiroki Kurita, Takatoshi Sorimachi, Koreaki Irie, Ichiro Nakahara, Nobutaka Horie, Yasuhiko Matsumori, Fusao Ikawa · 2026
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Description
Yusuke Inoue and co-authors study why patients stop a vessel-relaxing drug after brain aneurysm bleeding. Their twenty twenty-six registry study uses a national Japanese database on subarachnoid hemorrhage outcomes. Clazosentan cuts the vessel spasm that often follows such bleeds, and it has been used in Japan since twenty twenty-two.
The drug also brings body-wide side effects that can force a stop. The team sorted which clinical traits link to stopping the drug. They also probed how stopping relates to discharge state and six-month outcomes. Many centers feed the registry, so the pattern is broad. The work helps teams weigh who can stay on a useful but taxing drug.
Catalog record
| CREATOR | Yusuke Inoue, Masahito Katsuki, Toshikazu Hidaka, Yukishige Hashimoto, Yusuke Yamamoto, Daizo Ishii, Katsumi Takizawa, Yoji Tanaka, Masaki Chin, Motohiro Morioka, Hiroki Kurita, Takatoshi Sorimachi, Koreaki Irie, Ichiro Nakahara, Nobutaka Horie, Yasuhiko Matsumori, Fusao Ikawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |