1-Hydroxypyrene Promotes Bladder Cancer Progression and Tumor-Associated Immunosuppression via MIF
Yiting Liu, Zongyu Li, Yingchun Kuang, Ke Chen, Lilong Liu · 2026
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Description
Yiting Liu, Zongyu Li, Yingchun Kuang, Ke Chen, and Lilong Liu study how a pollutant breakdown product fuels bladder cancer and muffles immune attack, in a research paper from 2026. The compound, 1-hydroxypyrene, forms when the body processes certain smoke chemicals. The team screened shared targets between the compound and the cancer.
Machine learning narrowed twenty-nine shared targets to six genes, and one, called MIF, was tested in the lab. Treating cancer cells with the compound sped their growth, movement, and invasion. Silencing MIF partly reversed those gains. The compound also blunted killer T cells grown beside the tumor cells. The work names a pathway for pollution-linked cancer.
Catalog record
| CREATOR | Yiting Liu, Zongyu Li, Yingchun Kuang, Ke Chen, Lilong Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |