Implications of HIV persistence and pathogenesis in microglia
Nanouk Zuidmeer, Jori Symons, Monique Nijhuis · 2026
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Description
Nanouk Zuidmeer, Jori Symons, and Monique Nijhuis review, in a 2026 article, how HIV persists in microglia, the brain's resident immune cells, even when treatment suppresses the virus in blood. Microglia can carry complete, wakeable copies of the virus, tucked into different chromosome spots than in blood immune cells.
Infected and even nearby uninfected microglia turn inflammatory and age-like, feeding brain injury, and therapy calms but does not fully reverse that state. Cure efforts, the authors argue, must reach this brain reservoir and quiet viral activity there. The review sets priorities for researchers aiming at a complete HIV cure rather than control alone.
Catalog record
| CREATOR | Nanouk Zuidmeer, Jori Symons, Monique Nijhuis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22452 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |