Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3
Amira Khaled Abdelhamid, Fabiola Pedrini, Jennifer Schmitt, Ibrahim Hassan Fayed, Aya Osama, Hannah H. Rashwan, Diana M.F. Hanna, Esther T. Menze, Sameh Magdeldin, Marcin Luzarowski, Carsten Sticht, Ebtehal El-Demerdash, Kai Breuhahn, Ahmed Ihab Abdelaziz, Nada El-Ekiaby · 2026
Read Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3 by Amira Khaled Abdelhamid, Fabiola Pedrini, Jennifer Schmitt, Ibrahim Hassan Fayed, Aya Osama, Hannah H. Rashwan, Diana M.F. Hanna, Esther T. Menze, Sameh Magdeldin, Marcin Luzarowski, Carsten Sticht, Ebtehal El-Demerdash, Kai Breuhahn, Ahmed Ihab Abdelaziz, Nada El-Ekiaby (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566411.txt.
Description
Abdelhamid and co-authors trace a driver of liver scarring in a 2026 study. Two gene switches, YAP and TAZ, are known to wake hepatic stellate cells, the cells that lay down scar tissue. Less was known about their side partners and the long non coding RNAs they control. Using a proximity tagging method and gene sequencing in a human cell line, the team mapped those partners.
A factor called Kaiso turned up as a fresh partner of TAZ, confirmed by a second assay. Silencing Kaiso curbed key steps of stellate cell activation. The team also tied the pair to a long RNA named in the title, which sits downstream of the switch. The results add parts to the scarring program that drug hunters may one day target.
Catalog record
| CREATOR | Amira Khaled Abdelhamid, Fabiola Pedrini, Jennifer Schmitt, Ibrahim Hassan Fayed, Aya Osama, Hannah H. Rashwan, Diana M.F. Hanna, Esther T. Menze, Sameh Magdeldin, Marcin Luzarowski, Carsten Sticht, Ebtehal El-Demerdash, Kai Breuhahn, Ahmed Ihab Abdelaziz, Nada El-Ekiaby |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |