Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies
Jessica L Bloom, Indira Sriram · 2026
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Description
Jessica L. Bloom and Indira Sriram review, in a 2026 article, immune system problems in children and adults with Down syndrome, whose extra chromosome reshapes immunity toward inflammation and autoimmunity. Arthritis linked to Down syndrome is described as a distinct, aggressive illness, separate from other childhood arthritis forms.
Risks include severe lung disease tied to systemic arthritis and bleeding into the lungs. Standard drugs can be hard to tolerate or less effective in this group, with poor tolerance of one common drug and weaker responses to another class. Early trials of a newer drug family that calms interferon signaling look promising across skin, joint, and regression symptoms.
Catalog record
| CREATOR | Jessica L Bloom, Indira Sriram |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22366 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |