Primary Tumor Epigenetic and Transcriptomic Alterations Associated with Nodal Burden and Metastatic Risk in ER+/HER2− Breast Cancer
Sandra Iñiguez-Muñoz, Andrés F. Bedoya-López, Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Sookyung Ahn, Rachel E. Factor, Diego M. Marzese, Maggie L. DiNome · 2026
Read Primary Tumor Epigenetic and Transcriptomic Alterations Associated with Nodal Burden and Metastatic Risk in ER+/HER2− Breast Cancer by Sandra Iñiguez-Muñoz, Andrés F. Bedoya-López, Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Sookyung Ahn, Rachel E. Factor, Diego M. Marzese, Maggie L. DiNome (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566309.txt.
Description
Sandra Iniguez-Munoz and seven co-authors looked for gene marks in breast tumors that track how far cancer has spread to lymph nodes in a 2026 study. The cancer type feeds on estrogen but not a second growth signal. With less node surgery now done, that spread must be guessed from the tumor itself more often.
Gene-control marks in tumors from forty-seven patients differed by spread level, mostly at genes for development and cell sticking. Pairing those marks with gene activity and outcome data gave four genes and a score built from them. Low scores ran with spread tumors and shorter time before distant return in a large cohort, though the score overlapped with tumor grade. The authors say tumors carry the stamp of their spread early.
Catalog record
| CREATOR | Sandra Iñiguez-Muñoz, Andrés F. Bedoya-López, Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Sookyung Ahn, Rachel E. Factor, Diego M. Marzese, Maggie L. DiNome |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |