Peripheral Mononuclear Cells Metabolomics in Obstructive Sleep Apnea Syndrome (OSAS): An Exploratory Pilot Study of Immunometabolic Signatures
Nour Balasan, Michela Zorzi, Blendi Ura, Antonietta Robino, Paolo Dalena, Riccardo Addobbati, Mariateresa Di Stazio, Alessandro Zago, Adamo Pio d’Adamo, Domenico Leonardo Grasso, Alberto Tommasini, Egidio Barbi, Feras Kharrat · 2026
Read Peripheral Mononuclear Cells Metabolomics in Obstructive Sleep Apnea Syndrome (OSAS): An Exploratory Pilot Study of Immunometabolic Signatures by Nour Balasan, Michela Zorzi, Blendi Ura, Antonietta Robino, Paolo Dalena, Riccardo Addobbati, Mariateresa Di Stazio, Alessandro Zago, Adamo Pio d’Adamo, Domenico Leonardo Grasso, Alberto Tommasini, Egidio Barbi, Feras Kharrat (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566245.txt.
Description
Nour Balasan and co-authors profile the chemistry inside immune cells of people whose breathing stops repeatedly in sleep, in a 2026 pilot paper. The condition, obstructive sleep apnea, is tied to body-wide inflammation and immune trouble, but the chemical state of the immune cells themselves was little known. The team compared blood immune cells from patients and healthy controls, scanning hundreds of small molecules.
Twenty-one molecules first looked different between the groups, hinting at drained fuel carriers and shifts in fat and nerve-signal chemistry. After strict correction for the many comparisons, only one molecule, a form of muconic acid, stayed firmly significant. Pathway checks pointed loosely at transport across cell membranes and energy handling. The authors stress that most shifts are early hints, not proof, especially since few participants had full sleep-study data. Larger cohorts must test the leads.
Catalog record
| CREATOR | Nour Balasan, Michela Zorzi, Blendi Ura, Antonietta Robino, Paolo Dalena, Riccardo Addobbati, Mariateresa Di Stazio, Alessandro Zago, Adamo Pio d’Adamo, Domenico Leonardo Grasso, Alberto Tommasini, Egidio Barbi, Feras Kharrat |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |