Association Between Biopsy PD-L1 Combined Positive Score and Pathological Upgrading at Radical Prostatectomy in Grade Group 1 Prostate Cancer: A Retrospective Study
Ludovica Pepe, Valeria Zuccalà, Ida Rizzuto, Walter Giuseppe Giordano, Mariagiovanna Ballato, Pietro Tralongo, Gabriele Ricciardi, Vincenzo Cianci, Marta Rossanese, Giuseppe Iatì, Silvana Parisi, Francesco Pierconti, Antonio Ieni, Guido Fadda, Pietro Pepe, Maurizio Martini, Vincenzo Fiorentino · 2026
Read Association Between Biopsy PD-L1 Combined Positive Score and Pathological Upgrading at Radical Prostatectomy in Grade Group 1 Prostate Cancer: A Retrospective Study by Ludovica Pepe, Valeria Zuccalà, Ida Rizzuto, Walter Giuseppe Giordano, Mariagiovanna Ballato, Pietro Tralongo, Gabriele Ricciardi, Vincenzo Cianci, Marta Rossanese, Giuseppe Iatì, Silvana Parisi, Francesco Pierconti, Antonio Ieni, Guido Fadda, Pietro Pepe, Maurizio Martini, Vincenzo Fiorentino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566208.txt.
Description
Ludovica Pepe and fifteen colleagues test whether a biopsy marker can warn that low-grade prostate cancer is worse than it looks, in a 2026 study. Men graded lowest on biopsy sometimes prove higher grade once the gland is removed, a surprise called upgrading.
The two-center study matched eighty-six upgraded men with eighty-six who stayed low grade. A positive PD-L1 score on the biopsy appeared in about forty-two percent of upgraded cases against twenty-one percent of controls. The link held after adjusting for blood markers, core counts, imaging class, and center. The authors caution that no best cutoff or clinical use is proven yet, and call for prospective validation, including men on active surveillance.
Catalog record
| CREATOR | Ludovica Pepe, Valeria Zuccalà, Ida Rizzuto, Walter Giuseppe Giordano, Mariagiovanna Ballato, Pietro Tralongo, Gabriele Ricciardi, Vincenzo Cianci, Marta Rossanese, Giuseppe Iatì, Silvana Parisi, Francesco Pierconti, Antonio Ieni, Guido Fadda, Pietro Pepe, Maurizio Martini, Vincenzo Fiorentino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |