LEAP2 Regulates Insulin Secretion from INS-1E Beta Cells and Rat Pancreatic Islets: An In Vitro Study
Oskar Sosiński, Ewa Pruszyńska-Oszmałek, Maciej Sassek, Natalia Leciejewska, Piotr Pawlak, Paweł Antoni Kołodziejski · 2026
Read LEAP2 Regulates Insulin Secretion from INS-1E Beta Cells and Rat Pancreatic Islets: An In Vitro Study by Oskar Sosiński, Ewa Pruszyńska-Oszmałek, Maciej Sassek, Natalia Leciejewska, Piotr Pawlak, Paweł Antoni Kołodziejski (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566172.txt.
Description
Oskar Sosiński and co-authors present a study dated 2026 on a hormone signal that may tune insulin release. The molecule, LEAP2, blocks the receptor for ghrelin, a hormone tied to hunger and blood sugar. Its direct effects on the pancreas were not well mapped.
Experiments used a rat beta cell line and isolated rat pancreatic islets. Short exposure to the molecule raised basal insulin release in both systems. In the cell line it raised insulin protein after six hours and a signaling partner after twenty-four. In islets it raised one insulin gene's activity and lowered the ghrelin receptor's. The molecule did not harm cell growth or survival in the tests. The authors say more work with standard glucose challenges is needed.
Catalog record
| CREATOR | Oskar Sosiński, Ewa Pruszyńska-Oszmałek, Maciej Sassek, Natalia Leciejewska, Piotr Pawlak, Paweł Antoni Kołodziejski |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |