Jaceidin Inhibits Proliferation and Promotes Apoptosis in Oral Squamous Cell Carcinoma Cells by Regulating Survivin and AKT/ERK Signaling Pathways
Ming-Ju Hsieh, Hsin-Yu Ho, Chia-Chieh Lin, Min-Yun Kao, Yu-Sheng Lo, Yi-Ching Chuang, Bharath Kumar Velmurugan, Mu-Kuan Chen · 2026
Read Jaceidin Inhibits Proliferation and Promotes Apoptosis in Oral Squamous Cell Carcinoma Cells by Regulating Survivin and AKT/ERK Signaling Pathways by Ming-Ju Hsieh, Hsin-Yu Ho, Chia-Chieh Lin, Min-Yun Kao, Yu-Sheng Lo, Yi-Ching Chuang, Bharath Kumar Velmurugan, Mu-Kuan Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13566056.txt.
Description
Ming-Ju Hsieh and co-authors test a plant flavonoid against oral cancer cells, in work from 2026. Mouth cancer returns often and resists treatment in advanced stages. Natural compounds with low side effects are hunted as fresh candidates.
Two oral cancer cell lines were dosed with the compound, jaceidin. Growth and colony formation fell as dose and time rose. Cells piled up at a late division checkpoint, with key cycle proteins dropping. Death signals fired through both internal and receptor pathways, shown by cleaved enzymes. A survival protein fell while stress pathways shifted. The compound attacks growth and survival on several fronts at once.
Catalog record
| CREATOR | Ming-Ju Hsieh, Hsin-Yu Ho, Chia-Chieh Lin, Min-Yun Kao, Yu-Sheng Lo, Yi-Ching Chuang, Bharath Kumar Velmurugan, Mu-Kuan Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |