Targeting Latent Tuberculosis: Immunogenic Evaluation of a Mycobacterium tuberculosis Dormancy Antigen as a Vaccine Candidate
Rocío Zuazo, Ana Julia Bazán Bouyrie, Agustín Daniel Vitti, María Paula Morelli, Candela Martin, Javier Santos, Rosa Musella, Domingo Juan Palmero, Gabriela Calamante, María Paula Del Médico Zajac, Nicolás Oscar Amiano, Verónica Edith García · 2026
Read Targeting Latent Tuberculosis: Immunogenic Evaluation of a Mycobacterium tuberculosis Dormancy Antigen as a Vaccine Candidate by Rocío Zuazo, Ana Julia Bazán Bouyrie, Agustín Daniel Vitti, María Paula Morelli, Candela Martin, Javier Santos, Rosa Musella, Domingo Juan Palmero, Gabriela Calamante, María Paula Del Médico Zajac, Nicolás Oscar Amiano, Verónica Edith García (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565904.txt.
Description
Rocío Zuazo and co-authors evaluate a dormancy antigen in 2026 as a tuberculosis vaccine candidate. About two billion people carry the TB bacterium in latent form, and it can wake years later. Vaccines should target both growing and dormant stages, yet dormancy antigens are rarely tested.
Their antigen triggers immune responses mainly in people with latent infection, raising several helpful T cell types. The team maps which parts of the protein the immune system notices most. A viral-vector vaccine carrying the antigen cuts bacterial load in the spleens of challenged mice. The authors propose adding this antigen to multi-stage vaccine designs.
Catalog record
| CREATOR | Rocío Zuazo, Ana Julia Bazán Bouyrie, Agustín Daniel Vitti, María Paula Morelli, Candela Martin, Javier Santos, Rosa Musella, Domingo Juan Palmero, Gabriela Calamante, María Paula Del Médico Zajac, Nicolás Oscar Amiano, Verónica Edith García |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |