Molecular and Genomic Mechanisms Linking Diabetes Mellitus and Periodontitis: From Pathogenesis to Translational Opportunities
Nozomi Harai, Kyoichiro Tsuchiya · 2026
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Description
Nozomi Harai and Kyoichiro Tsuchiya review how diabetes and gum disease feed each other at the molecular level, in this 2026 paper. The two chronic conditions are linked both ways: high blood sugar worsens gum breakdown, and gum inflammation worsens sugar control. The review pulls together evidence from cells, genes, microbes, and patients.
High sugar drives chemical tags that switch on inflammation routes, raise oxidative stress, and fire a cellular alarm complex, all of which injure gum tissue. Immune cells also misbehave, and the balance tips toward bone eating cells that loosen teeth. In the other direction, gum microbes and their products stoke body wide inflammation and insulin resistance. Genetic studies find shared risk spots. The authors see room for joint medical and dental care, while noting causal proof is still incomplete.
Catalog record
| CREATOR | Nozomi Harai, Kyoichiro Tsuchiya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |