Behaviour of iPSC-Derived and Donor-Derived Hepatic Stellate Cells in Organoid Cultures Is Highly Variable and Contributes to Fibrotic Outcome
Yuwei Yang, Mina Kazemzadeh Dastjerd, Ayla Smout, Vincent Merens, Burak Toprakhisar, Catherine M. Verfaillie, Christophe Chesné, Leo A. van Grunsven · 2026
Read Behaviour of iPSC-Derived and Donor-Derived Hepatic Stellate Cells in Organoid Cultures Is Highly Variable and Contributes to Fibrotic Outcome by Yuwei Yang, Mina Kazemzadeh Dastjerd, Ayla Smout, Vincent Merens, Burak Toprakhisar, Catherine M. Verfaillie, Christophe Chesné, Leo A. van Grunsven (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565511.txt.
Description
Yuwei Yang and co-authors warn that the star cells inside lab-grown liver tissue vary wildly by source, in a 2026 study. Hepatic stellate cells drive liver scarring, yet organoid builders often treat them as uniform. The team grew organoids with stem-cell-made stellate cells from two lines, and with donor cells, alongside liver-like cells.
One line's organoids made far more of a key liver enzyme, while the other's showed about four times more scar staining. Single-cell profiles backed the split, and donor cells differed just as much, at rest and under drug injury. The message for drug testers is blunt: the stellate cell source can decide the result.
Catalog record
| CREATOR | Yuwei Yang, Mina Kazemzadeh Dastjerd, Ayla Smout, Vincent Merens, Burak Toprakhisar, Catherine M. Verfaillie, Christophe Chesné, Leo A. van Grunsven |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |