TPPP3 Overexpression Suppresses Nasopharyngeal Carcinoma Progression and Promotes Immune Microenvironment Remodeling Through HSPA8 Association
Shengwei Li, Jiejun Liao, Jiawei Yang, Yanfeng Han, Zixiao Lei, Zheng Yang · 2026
Read TPPP3 Overexpression Suppresses Nasopharyngeal Carcinoma Progression and Promotes Immune Microenvironment Remodeling Through HSPA8 Association by Shengwei Li, Jiejun Liao, Jiawei Yang, Yanfeng Han, Zixiao Lei, Zheng Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565496.txt.
Description
Shengwei Li, Jiejun Liao, Jiawei Yang, Yanfeng Han, Zixiao Lei, and Zheng Yang probe a protein that slows nasopharyngeal cancer in work dated two thousand twenty-six. That throat cancer grows in an immune-shielded setting that often blunts treatment. The protein TPPP3 had been flagged as a brake on the cancer's aggression, with its immune role unclear.
Cell lines of the cancer were made to overproduce the protein, then grown as tumors in humanized mice. Extra protein curbed growth and reshaped immune cell entry into the tumors. A partner hunt by pull-down and mass reading named the chaperone HSPA8 as its mate. Blocking that partner with a drug let some aggression return in dish and animal tests. The pair may offer a fresh drug target.
Catalog record
| CREATOR | Shengwei Li, Jiejun Liao, Jiawei Yang, Yanfeng Han, Zixiao Lei, Zheng Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |