Bezafibrate and Cholic Acid-Mediated Lipid Reduction Improves the Cryotolerance of Vitrified In Vivo-Derived Porcine Embryos
Jiehuan Xu, Mengqian He, Jun Gao, Lingwei Sun, Yuan Zhou, Caifeng Wu, Shushan Zhang, Defu Zhang, Jianjun Dai · 2026
Read Bezafibrate and Cholic Acid-Mediated Lipid Reduction Improves the Cryotolerance of Vitrified In Vivo-Derived Porcine Embryos by Jiehuan Xu, Mengqian He, Jun Gao, Lingwei Sun, Yuan Zhou, Caifeng Wu, Shushan Zhang, Defu Zhang, Jianjun Dai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565250.txt.
Description
Xu and co-authors try to make frozen pig embryos survive thawing better. Fat stored inside the embryo is the main barrier, so they test two fat-lowering drugs, bezafibrate and cholic acid, alone and together, while embryos grow from an early stage in the lab. Treated embryos are then frozen, warmed, and checked for fat, growth, and pregnancy after transfer.
The pair at a mid dose clears the most fat without harm and lifts growth after warming, with a hint of better pregnancy rates. A dose four times higher, though, harms development. The authors offer the pairing as a practical recipe for pig embryo freezing programs.
Catalog record
| CREATOR | Jiehuan Xu, Mengqian He, Jun Gao, Lingwei Sun, Yuan Zhou, Caifeng Wu, Shushan Zhang, Defu Zhang, Jianjun Dai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |