Integrated Time-Series Biochemical, Transcriptomic and Metabolomic Analyses Reveal Key Pathways and Concentration-Dependent Transitions in Chironomid Larvae (Propsilocerus akamusi) Under Chlorantraniliprole Stress
Jiani Li, Wei Chen, Jian Mao, Runze Li, Chuncai Yan, Zeyang Sun · 2026
Read Integrated Time-Series Biochemical, Transcriptomic and Metabolomic Analyses Reveal Key Pathways and Concentration-Dependent Transitions in Chironomid Larvae (Propsilocerus akamusi) Under Chlorantraniliprole Stress by Jiani Li, Wei Chen, Jian Mao, Runze Li, Chuncai Yan, Zeyang Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565220.txt.
Description
Jiani Li and five co-authors published an ecotoxicology study in twenty twenty-six on how a common insecticide stresses midge larvae over time. Chironomid larvae tolerate many pollutants, yet the molecular effects of chlorantraniliprole were unclear. The team exposed Propsilocerus akamusi larvae to low and high doses and sampled at two time points.
Biochemical tests, metabolomics, and gene expression profiling were combined into one picture. The pesticide raised antioxidant enzymes and protein damage, worst at the high dose. Early responses defended against oxidation, while later ones shifted toward protein repair or, at the high dose, energy collapse. Silencing a heat-shock gene confirmed its protective role. The timeline shows dose deciding between adaptation and breakdown.
Catalog record
| CREATOR | Jiani Li, Wei Chen, Jian Mao, Runze Li, Chuncai Yan, Zeyang Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |