Histology-Correlated FTIR Chemical Imaging of Fungal Infection-Associated Tissue Compartments in Human Skin: A Proof-of-Concept Study
Maximilian Lammer, Paul Bellmann, Matthias Schmuth, Verena Moosbrugger-Martinz, Bernhard Zelger, Bettina Zelger, Birgit Moser, Petra Hatzer-Grubwieser, Claudia Wöss, Roland Stalder, Lisa-Maria Zenz, Michaela Lackner, Christian Wolfgang Huck, Miranda Klosterhuber, Johannes Dominikus Pallua · 2026
Read Histology-Correlated FTIR Chemical Imaging of Fungal Infection-Associated Tissue Compartments in Human Skin: A Proof-of-Concept Study by Maximilian Lammer, Paul Bellmann, Matthias Schmuth, Verena Moosbrugger-Martinz, Bernhard Zelger, Bettina Zelger, Birgit Moser, Petra Hatzer-Grubwieser, Claudia Wöss, Roland Stalder, Lisa-Maria Zenz, Michaela Lackner, Christian Wolfgang Huck, Miranda Klosterhuber, Johannes Dominikus Pallua (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565212.txt.
Description
Maximilian Lammer and fourteen co-authors test whether infrared light maps can spot fungal infection inside skin tissue. Standard lab work relies on stains that show structure but little chemistry. The imaging method used here reads how each tiny spot absorbs infrared light, building a chemical picture with no labels at all. The team studied archived skin samples with proven fungal infection and matched the images to stained sections from the same tissue.
Twelve cases passed quality checks, giving 46 marked regions across infected tissue, hardened surface tissue, and living epidermis. Infected regions showed partly distinct spectral fingerprints, strongest in one mid-range band, and differed clearly from living epidermis at two measured points. Hardened tissue overlapped much more, which limits clean separation. Cluster maps still traced the tissue compartments well. The authors offer the method as a chemical companion to standard pathology.
Catalog record
| CREATOR | Maximilian Lammer, Paul Bellmann, Matthias Schmuth, Verena Moosbrugger-Martinz, Bernhard Zelger, Bettina Zelger, Birgit Moser, Petra Hatzer-Grubwieser, Claudia Wöss, Roland Stalder, Lisa-Maria Zenz, Michaela Lackner, Christian Wolfgang Huck, Miranda Klosterhuber, Johannes Dominikus Pallua |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |